Keywords

• Pnc-27
• Pnc27
• Pnc27 peptide

Quick Details

• ProName: Anti Cancer Peptide Pnc-27/Pnc27 5mg/V...
• CasNo: 104987-11-3
• Molecular Formula: C84H128N18O24
• Appearance: white
• Application: peptides
• DeliveryTime: 7-10 days
• PackAge: drum
• Port: Shanghai/Wuhan
• ProductionCapacity: 100 bottle/Day
• Purity: 99
• Storage: room
• LimitNum: 1 box

Superiority

name: PNC-27
Molecular formula: C84H128N18O24
Molecular weight: 1772.93
Purity:  >98.0%
Specication : 5mg/vial, 10vials/box

Details

Anti Cancer Peptide Pnc-27/Pnc27 5mg/Vial Powder

PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in contrast to the effects of many chemotherapeutic agents.