Keywords

• Acalabrutinib
• Acalabrutinib powder
• 99% Acalabrutinib

Quick Details

• ProName: cas 1420477-60-6 Acalabrutinib powde...
• CasNo: 1420477-60-6
• Molecular Formula: C26H23N7O2
• Appearance: white
• Application: Artemisia annua is used as antimalaria...
• DeliveryTime: 7-10 days
• PackAge: drum
• Port: Shanghai/Wuhan
• ProductionCapacity: 1000 Kilogram/Day
• Purity: 99
• Storage: room
• LimitNum: 1 Kilogram

Superiority

cas  1420477-60-6  Acalabrutinib powder 

Details

What is Acalabrutinib
Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.

Acalabrutinib function
Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).