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CAS NO.24280-93-1
cas 24280-93-1 99% Mycophenolic acid powder
Product Name: Mycophenolic acid
CAS: 24280-93-1
MF: C17H20O6
MW: 320.34
EINECS: 246-119-3
cas 24280-93-1 99% Mycophenolic acid powder
Product Name: Mycophenolic acid
CAS: 24280-93-1
MF: C17H20O6
MW: 320.34
EINECS: 246-119-3
Mycophenolic acid, less accurately called mycophenolate, is a compound derived from Penicillium stoloniferum and related species. It can reversibly inhibit inosine monophosphate dehydrogenase (IMPDH), the enzyme that controls the rate of synthesis of guanine monophosphate in the de novo pathway of purine synthesis used in the proliferation of B and T lymphocytes. Mycophenolic acid also has antibacterial, anticancer, antifungal, and antiviral activities. These powerful properties have been exploited in studies on organ transplant survival, anti-proliferative, rheumatoid arthritis, and psoriasis. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to improve oral bioavailability. More recently, the salt mycophenolate sodium has also been introduced.
mycophenolic acid was the first antibiotic to be synthesised in pure and crystalline form. But its medical application was forgotten until two American scientists C.L. Alsberg and O.M. Black resynthesised it in 1912, and gave its chemical name. It was eventually found to be a broad-spectrum acting drug having antiviral, antifungal, antibacterial, anticancer, and antipsoriasis properties.