Keywords

• Neratinib
• Neratinib powder
• 99% Neratinib

Quick Details

• ProName: cas 698387-09-6 99% Neratinib powder
• CasNo: 698387-09-6
• Molecular Formula: C30H29ClN6O3
• Appearance: white
• Application: Anti cancer
• DeliveryTime: 7-10 days
• PackAge: drum
• Port: Shanghai/Wuhan
• ProductionCapacity: 1000 Kilogram/Day
• Purity: 99
• Storage: room
• LimitNum: 1 Kilogram

Superiority

cas 698387-09-6 99% Neratinib  powder

Details

What is Neratinib

The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib .

Neratinib Function

Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations. Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively. irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Antitumor agent