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CAS NO.960539-70-2
cas 960539-70-2 99% purity daprodustat powder
Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.
daprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes.